EPS8L1 (EPS8 signaling adaptor L1) - Rat Genome Database

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Gene: EPS8L1 (EPS8 signaling adaptor L1) Pan paniscus
Analyze
Symbol: EPS8L1
Name: EPS8 signaling adaptor L1 (Ensembl:EPS8 like 1)
RGD ID: 11747866
Description: ENCODES a protein that exhibits guanyl-nucleotide exchange factor activity (ortholog); INVOLVED IN positive regulation of ruffle assembly (inferred); regulation of Rho protein signal transduction (inferred); Rho protein signal transduction (inferred); FOUND IN cytosol (inferred); plasma membrane (inferred); protein-containing complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: epidermal growth factor receptor kinase substrate 8-like protein 1; EPS8 like 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,208,539 - 61,220,500 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,937,956 - 62,949,917 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,114,011 - 52,125,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,807,691 - 60,819,833 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,803,996 - 60,819,833 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
EPS8L1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22061,208,539 - 61,220,500 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11962,937,956 - 62,949,917 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01952,114,011 - 52,125,981 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11960,807,691 - 60,819,833 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1960,803,996 - 60,819,833 (+)Ensemblpanpan1.1panPan2
EPS8L1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381955,075,869 - 55,087,923 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1955,072,020 - 55,087,923 (+)EnsemblGRCh38hg38GRCh38
GRCh371955,587,237 - 55,599,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,279,033 - 60,291,103 (+)NCBINCBI36Build 36hg18NCBI36
Celera1952,627,181 - 52,639,321 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,911,176 - 51,922,834 (+)NCBIHuRef
CHM1_11955,581,282 - 55,592,823 (+)NCBICHM1_1
T2T-CHM13v2.01958,170,549 - 58,182,414 (+)NCBIT2T-CHM13v2.0
Eps8l1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3974,463,636 - 4,483,486 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl74,463,673 - 4,483,486 (+)EnsemblGRCm39 Ensembl
GRCm3874,460,638 - 4,480,487 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl74,460,674 - 4,480,487 (+)EnsemblGRCm38mm10GRCm38
MGSCv3774,416,344 - 4,430,844 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3674,067,829 - 4,082,329 (+)NCBIMGSCv36mm8
Celera74,209,264 - 4,223,753 (+)NCBICelera
Cytogenetic Map7A1NCBI
cM Map72.58NCBI
Eps8l1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,386,916 - 78,409,972 (-)NCBIGRCr8
mRatBN7.2169,343,202 - 69,359,778 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,344,243 - 69,363,524 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx174,703,162 - 74,717,872 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,267,477 - 83,282,191 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,417,107 - 76,431,775 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0172,926,106 - 72,942,433 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl172,927,151 - 72,941,869 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0175,609,557 - 75,625,473 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,072,667 - 68,087,385 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,152,006 - 68,165,394 (-)NCBI
Celera167,769,206 - 67,783,928 (+)NCBICelera
Cytogenetic Map1q12NCBI
Eps8l1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555671,071,865 - 1,084,331 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555671,074,714 - 1,084,259 (-)NCBIChiLan1.0ChiLan1.0
EPS8L1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11102,517,894 - 102,528,733 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1102,518,054 - 102,527,938 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1102,574,952 - 102,585,788 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01103,171,471 - 103,182,307 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1103,171,713 - 103,182,486 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11102,808,382 - 102,819,216 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01102,519,935 - 102,530,695 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01103,284,250 - 103,295,084 (-)NCBIUU_Cfam_GSD_1.0
Eps8l1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244093492,170,294 - 2,179,019 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936886380,533 - 388,901 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936886380,533 - 388,931 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPS8L1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl659,310,334 - 59,323,372 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1659,310,258 - 59,322,662 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2654,343,327 - 54,355,073 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPS8L1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1647,668,258 - 47,679,750 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl647,670,493 - 47,680,536 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045222,945 - 234,645 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eps8l1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248322,124,670 - 2,138,828 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248322,124,674 - 2,134,130 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000063883   ⟹   ENSPPAP00000040962
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1960,803,996 - 60,819,526 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000063886   ⟹   ENSPPAP00000040965
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1960,810,511 - 60,819,833 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000063888   ⟹   ENSPPAP00000040967
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1960,811,599 - 60,815,702 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000063890   ⟹   ENSPPAP00000040969
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1960,812,313 - 60,819,833 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000063894   ⟹   ENSPPAP00000040973
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1960,812,417 - 60,819,526 (+)Ensembl
RefSeq Acc Id: XM_003809897   ⟹   XP_003809945
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22061,212,956 - 61,220,500 (+)NCBI
NHGRI_mPanPan11962,942,387 - 62,949,917 (+)NCBI
Mhudiblu_PPA_v01952,118,441 - 52,125,981 (+)NCBI
PanPan1.11960,812,313 - 60,819,833 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008962254   ⟹   XP_008960502
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22061,212,997 - 61,220,500 (+)NCBI
NHGRI_mPanPan11962,942,415 - 62,949,917 (+)NCBI
Mhudiblu_PPA_v01952,118,440 - 52,125,981 (+)NCBI
PanPan1.11960,812,313 - 60,819,833 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034946654   ⟹   XP_034802545
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22061,208,539 - 61,220,500 (+)NCBI
NHGRI_mPanPan11962,937,956 - 62,949,917 (+)NCBI
Mhudiblu_PPA_v01952,114,011 - 52,125,981 (+)NCBI
RefSeq Acc Id: XM_034946655   ⟹   XP_034802546
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22061,208,539 - 61,220,500 (+)NCBI
NHGRI_mPanPan11962,937,956 - 62,949,917 (+)NCBI
Mhudiblu_PPA_v01952,114,011 - 52,125,981 (+)NCBI
RefSeq Acc Id: XM_063599686   ⟹   XP_063455756
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22061,213,003 - 61,220,500 (+)NCBI
RefSeq Acc Id: XM_063599688   ⟹   XP_063455758
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22061,212,980 - 61,220,500 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_008960502   ⟸   XM_008962254
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_003809945   ⟸   XM_003809897
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_034802545   ⟸   XM_034946654
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034802546   ⟸   XM_034946655
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000040967   ⟸   ENSPPAT00000063888
RefSeq Acc Id: ENSPPAP00000040965   ⟸   ENSPPAT00000063886
RefSeq Acc Id: ENSPPAP00000040962   ⟸   ENSPPAT00000063883
RefSeq Acc Id: ENSPPAP00000040969   ⟸   ENSPPAT00000063890
RefSeq Acc Id: ENSPPAP00000040973   ⟸   ENSPPAT00000063894
RefSeq Acc Id: XP_063455758   ⟸   XM_063599688
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063455756   ⟸   XM_063599686
- Peptide Label: isoform X4
Protein Domains
PTB   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043107 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000063883.1 UniProtKB/TrEMBL
  ENSPPAT00000063886.1 UniProtKB/TrEMBL
  ENSPPAT00000063888.1 UniProtKB/TrEMBL
  ENSPPAT00000063890.1 UniProtKB/TrEMBL
  ENSPPAT00000063894.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
InterPro EPS8-like UniProtKB/TrEMBL
  EPS8_PTB UniProtKB/TrEMBL
  Eps8_SH3 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PTB UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  SAM_3 UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
KEGG Report pps:100996162 UniProtKB/TrEMBL
NCBI Gene EPS8L1 ENTREZGENE
PANTHER EPIDERMAL GROWTH FACTOR RECEPTOR KINASE SUBSTRATE 8-LIKE PROTEIN 1 UniProtKB/TrEMBL
  PTHR12287 UniProtKB/TrEMBL
Pfam PTB UniProtKB/TrEMBL
  SAM_3 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PROSITE SH3 UniProtKB/TrEMBL
SMART SH3 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF50044 UniProtKB/TrEMBL
UniProt A0A2R9CG84_PANPA UniProtKB/TrEMBL
  A0A2R9CGC9_PANPA UniProtKB/TrEMBL
  A0A2R9CIX1_PANPA UniProtKB/TrEMBL
  A0A2R9CQH8_PANPA UniProtKB/TrEMBL
  A0A2R9CQI0_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-11-15 EPS8L1  EPS8 signaling adaptor L1  EPS8L1  EPS8 like 1  Symbol and/or name change 5135510 APPROVED