LRFN5 (leucine rich repeat and fibronectin type III domain containing 5) - Rat Genome Database

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Gene: LRFN5 (leucine rich repeat and fibronectin type III domain containing 5) Pan paniscus
Analyze
Symbol: LRFN5
Name: leucine rich repeat and fibronectin type III domain containing 5
RGD ID: 11742565
Description: INVOLVED IN negative regulation of inflammatory response (inferred); negative regulation of macrophage activation (inferred); regulation of presynapse assembly (inferred); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); genetic disease (ortholog); FOUND IN GABA-ergic synapse (ortholog); glutamatergic synapse (ortholog); postsynaptic density membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine-rich repeat and fibronectin type-III domain-containing protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21542,740,303 - 43,035,903 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11441,956,817 - 42,252,417 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01422,185,289 - 22,480,641 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11440,519,143 - 40,814,212 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1440,676,278 - 40,814,212 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
LRFN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21542,740,303 - 43,035,903 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11441,956,817 - 42,252,417 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01422,185,289 - 22,480,641 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11440,519,143 - 40,814,212 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1440,676,278 - 40,814,212 (+)Ensemblpanpan1.1panPan2
LRFN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381441,606,876 - 41,904,549 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1441,606,876 - 41,904,549 (+)EnsemblGRCh38hg38GRCh38
GRCh371442,076,079 - 42,373,752 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361441,147,090 - 41,443,499 (+)NCBINCBI36Build 36hg18NCBI36
Build 341441,147,093 - 41,443,498NCBI
Celera1421,937,439 - 22,234,297 (+)NCBICelera
Cytogenetic Map14q21.1NCBI
HuRef1422,187,067 - 22,483,854 (+)NCBIHuRef
CHM1_11442,014,900 - 42,311,898 (+)NCBICHM1_1
T2T-CHM13v2.01435,797,646 - 36,095,321 (+)NCBIT2T-CHM13v2.0
Lrfn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391261,569,356 - 61,913,554 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1261,569,936 - 61,905,128 (+)EnsemblGRCm39 Ensembl
GRCm381261,522,851 - 61,857,928 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1261,523,150 - 61,858,342 (+)EnsemblGRCm38mm10GRCm38
MGSCv371262,625,619 - 62,946,245 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361262,442,645 - 62,763,271 (+)NCBIMGSCv36mm8
Celera1262,712,498 - 63,024,396 (+)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1226.43NCBI
Lrfn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8685,201,465 - 85,557,872 (+)NCBIGRCr8
mRatBN7.2679,466,403 - 79,822,821 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl679,467,961 - 79,822,815 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx679,870,429 - 80,226,228 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0680,169,774 - 80,525,588 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0679,605,241 - 79,960,964 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0683,082,593 - 83,438,601 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl683,083,740 - 83,438,601 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0692,601,831 - 92,958,936 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4682,482,116 - 82,656,279 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1682,889,667 - 82,906,372 (+)NCBI
Celera678,123,282 - 78,474,424 (+)NCBICelera
Cytogenetic Map6q23NCBI
Lrfn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540919,710,305 - 19,856,123 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540919,710,527 - 19,969,984 (-)NCBIChiLan1.0ChiLan1.0
LRFN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1819,365,786 - 19,602,551 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl819,367,570 - 19,602,185 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha819,177,231 - 19,413,096 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0819,508,003 - 19,744,373 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl819,509,804 - 19,745,878 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1819,183,646 - 19,420,029 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0819,256,859 - 19,493,267 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0819,517,360 - 19,753,738 (+)NCBIUU_Cfam_GSD_1.0
Lrfn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864051,402,747 - 51,649,903 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649415,138,854 - 15,156,555 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649414,908,783 - 15,155,797 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRFN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1171,906,198 - 172,177,720 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11171,906,130 - 172,177,726 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21191,439,600 - 191,710,127 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LRFN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12418,421,057 - 18,712,096 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2418,568,568 - 18,712,609 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660537,563,895 - 7,851,872 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrfn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462481311,049,888 - 11,196,095 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462481310,930,009 - 11,196,036 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000059444   ⟹   ENSPPAP00000036552
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1440,676,278 - 40,813,839 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059449   ⟹   ENSPPAP00000036557
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1440,796,589 - 40,814,212 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059457   ⟹   ENSPPAP00000036565
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1440,796,622 - 40,813,834 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059460   ⟹   ENSPPAP00000036568
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1440,796,622 - 40,808,598 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059463   ⟹   ENSPPAP00000036571
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1440,796,622 - 40,805,238 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000059465   ⟹   ENSPPAP00000036572
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1440,796,622 - 40,805,173 (+)Ensembl
RefSeq Acc Id: XM_003831760   ⟹   XP_003831808
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21542,740,303 - 43,035,903 (+)NCBI
NHGRI_mPanPan11441,956,817 - 42,252,417 (+)NCBI
Mhudiblu_PPA_v01422,185,289 - 22,480,641 (+)NCBI
PanPan1.11440,519,143 - 40,814,212 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034937494   ⟹   XP_034793385
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21542,740,386 - 43,035,903 (+)NCBI
NHGRI_mPanPan11441,957,022 - 42,252,417 (+)NCBI
Mhudiblu_PPA_v01422,185,289 - 22,480,641 (+)NCBI
RefSeq Acc Id: XM_034937495   ⟹   XP_034793386
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21542,740,371 - 43,020,075 (+)NCBI
NHGRI_mPanPan11441,956,885 - 42,236,589 (+)NCBI
Mhudiblu_PPA_v01422,185,585 - 22,464,814 (+)NCBI
RefSeq Acc Id: XM_034937496   ⟹   XP_034793387
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21542,740,371 - 43,035,903 (+)NCBI
NHGRI_mPanPan11441,956,885 - 42,252,417 (+)NCBI
Mhudiblu_PPA_v01422,185,289 - 22,480,641 (+)NCBI
RefSeq Acc Id: XM_055097540   ⟹   XP_054953515
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21542,861,974 - 43,035,903 (+)NCBI
NHGRI_mPanPan11442,078,479 - 42,252,417 (+)NCBI
RefSeq Acc Id: XM_063596060   ⟹   XP_063452130
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21542,740,371 - 43,030,266 (+)NCBI
RefSeq Acc Id: XM_063596061   ⟹   XP_063452131
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21542,861,950 - 43,030,266 (+)NCBI
RefSeq Acc Id: XM_063596062   ⟹   XP_063452132
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21542,740,386 - 43,030,266 (+)NCBI
RefSeq Acc Id: XM_063596063   ⟹   XP_063452133
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21542,740,386 - 43,030,266 (+)NCBI
RefSeq Acc Id: XM_063596064   ⟹   XP_063452134
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21542,740,371 - 43,020,220 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003831808   ⟸   XM_003831760
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034793387   ⟸   XM_034937496
- Peptide Label: isoform X5
- UniProtKB: A0A2R9C6P0 (UniProtKB/TrEMBL),   A0A2R9C3Q4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034793385   ⟸   XM_034937494
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034793386   ⟸   XM_034937495
- Peptide Label: isoform X4
- UniProtKB: A0A2R9C3Q4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000036565   ⟸   ENSPPAT00000059457
RefSeq Acc Id: ENSPPAP00000036572   ⟸   ENSPPAT00000059465
RefSeq Acc Id: ENSPPAP00000036571   ⟸   ENSPPAT00000059463
RefSeq Acc Id: ENSPPAP00000036568   ⟸   ENSPPAT00000059460
RefSeq Acc Id: ENSPPAP00000036557   ⟸   ENSPPAT00000059449
RefSeq Acc Id: ENSPPAP00000036552   ⟸   ENSPPAT00000059444
RefSeq Acc Id: XP_054953515   ⟸   XM_055097540
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063452130   ⟸   XM_063596060
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063452134   ⟸   XM_063596064
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063452132   ⟸   XM_063596062
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063452133   ⟸   XM_063596063
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063452131   ⟸   XM_063596061
- Peptide Label: isoform X1
Protein Domains
Ig-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041037 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000059444.1 UniProtKB/TrEMBL
  ENSPPAT00000059449.1 UniProtKB/TrEMBL
  ENSPPAT00000059457.1 UniProtKB/TrEMBL
  ENSPPAT00000059460.1 UniProtKB/TrEMBL
  ENSPPAT00000059463.1 UniProtKB/TrEMBL
  ENSPPAT00000059465.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro FN3_sf UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100993345 UniProtKB/TrEMBL
NCBI Gene LRFN5 ENTREZGENE
PANTHER PTHR45842:SF10 UniProtKB/TrEMBL
  SYNAPTIC ADHESION-LIKE MOLECULE SALM UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
UniProt A0A2R9C3M2_PANPA UniProtKB/TrEMBL
  A0A2R9C3Q4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C6P0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CE13_PANPA UniProtKB/TrEMBL
  A0A2R9CE32_PANPA UniProtKB/TrEMBL