NR2E3 (nuclear receptor subfamily 2 group E member 3)

Gene: NR2E3 (nuclear receptor subfamily 2 group E member 3) Pan paniscus

Analyze

Symbol:

NR2E3

Name:

nuclear receptor subfamily 2 group E member 3

RGD ID:

11729277

Description:

ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN cell population proliferation (ortholog); eye photoreceptor cell development (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPATES IN retinitis pigmentosa pathway; ASSOCIATED WITH Bloom syndrome (ortholog); colorectal cancer (ortholog); cone-rod dystrophy (ortholog); FOUND IN cytoplasm (inferred); nucleoplasm (inferred); nucleus (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

photoreceptor-specific nuclear receptor

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	61,068,810 - 61,081,380 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	65,233,083 - 65,253,404 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	50,759,707 - 50,767,703 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	69,525,351 - 69,533,008 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	69,525,351 - 69,533,034 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

colorectal cancer (ISO)

cone-rod dystrophy (ISO)

enhanced S-cone syndrome (ISO)

Eye Abnormalities (ISO)

fundus dystrophy (ISO)

genetic disease (ISO)

Leber congenital amaurosis (ISO)

ocular albinism 1 (ISO)

retinitis pigmentosa (ISO)

retinitis pigmentosa 37 (ISO)

Tay-Sachs disease (ISO)

Vision Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IEA)

cell population proliferation (IEA,ISO)

eye photoreceptor cell development (IEA,ISO)

intracellular receptor signaling pathway (IEA)

negative regulation of cell population proliferation (IEA,ISO)

negative regulation of transcription by RNA polymerase II (IEA,ISO)

positive regulation of gene expression (IEA,ISO)

positive regulation of transcription by RNA polymerase II (IEA,ISO)

regulation of DNA-templated transcription (IEA)

retina development in camera-type eye (IEA,ISO)

steroid hormone mediated signaling pathway (IEA)

Cellular Component

cytoplasm (IEA)

nucleoplasm (IEA)

nucleus (IEA)

transcription regulator complex (IEA)

Molecular Function

DNA binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity (IEA)

metal ion binding (IEA)

nuclear receptor activity (IEA)

nuclear steroid receptor activity (IEA)

protein binding (ISO)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

transcription corepressor activity (IEA)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

retinitis pigmentosa pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

NR2E3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	61,068,810 - 61,081,380 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	65,233,083 - 65,253,404 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	50,759,707 - 50,767,703 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	69,525,351 - 69,533,008 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	15	69,525,351 - 69,533,034 (+)	Ensembl	panpan1.1		panPan2

NR2E3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	71,810,554 - 71,818,253 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	71,792,638 - 71,818,259 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	72,102,894 - 72,110,594 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	69,889,948 - 69,897,654 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	15	69,889,947 - 69,894,324	NCBI
Celera	15	48,989,266 - 48,996,967 (+)	NCBI		Celera
Cytogenetic Map	15	q23	NCBI
HuRef	15	48,933,359 - 48,941,065 (+)	NCBI		HuRef
CHM1_1	15	72,221,027 - 72,228,738 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	15	69,629,504 - 69,637,203 (+)	NCBI		T2T-CHM13v2.0

Nr2e3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	9	59,850,054 - 59,868,117 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	9	59,850,054 - 59,867,942 (-)	Ensembl		GRCm39 Ensembl
GRCm38	9	59,942,771 - 59,960,834 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	9	59,942,771 - 59,960,659 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	9	59,790,578 - 59,797,886 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	9	59,740,777 - 59,748,085 (-)	NCBI		MGSCv36	mm8
Celera	9	57,170,930 - 57,178,240 (-)	NCBI		Celera
Cytogenetic Map	9	B	NCBI
cM Map	9	32.35	NCBI

Nr2e3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	8	69,261,343 - 69,269,081 (-)	NCBI		GRCr8
mRatBN7.2	8	60,365,581 - 60,373,383 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	8	60,366,124 - 60,373,163 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	8	64,797,518 - 64,801,587 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	8	64,797,518 - 64,800,467 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	8	64,555,324 - 64,557,833 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	8	59,807,339 - 59,816,089 (-)	NCBI		Celera
Cytogenetic Map	8	q24	NCBI

Nr2e3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955450	5,281,707 - 5,286,260 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955450	5,281,707 - 5,286,260 (-)	NCBI	ChiLan1.0	ChiLan1.0

NR2E3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	30	35,375,181 - 35,382,398 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	30	35,309,120 - 35,318,785 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	30	35,578,487 - 35,588,153 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	30	35,582,048 - 35,588,151 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	30	35,529,407 - 35,539,055 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	30	35,561,018 - 35,567,025 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	30	35,811,616 - 35,821,244 (+)	NCBI		UU_Cfam_GSD_1.0

Nr2e3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	113,381,409 - 113,387,591 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936471	31,229,564 - 31,235,654 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936471	31,229,322 - 31,236,093 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NR2E3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	169,360,729 - 169,366,087 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	169,358,662 - 169,373,175 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	187,978,045 - 187,993,204 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NR2E3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	26	11,648,675 - 11,655,408 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	26	11,648,758 - 11,654,850 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666048	129,915,839 - 129,922,267 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Nr2e3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624781	2,202,614 - 2,207,782 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624781	2,201,656 - 2,210,495 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003818546	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	DQ977273	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JARIFH020000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000062764 ⟹ ENSPPAP00000039852

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	15	69,525,351 - 69,533,034 (+)	Ensembl

RefSeq Acc Id:

XM_003818546 ⟹ XP_003818594

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	16	61,068,810 - 61,081,380 (+)	NCBI
NHGRI_mPanPan1	15	65,233,083 - 65,253,404 (+)	NCBI
Mhudiblu_PPA_v0	15	50,759,707 - 50,767,703 (+)	NCBI
PanPan1.1	15	69,525,351 - 69,533,008 (+)	NCBI

Sequence:

show sequence

CCCGGGAGAAATCTCCTCAAGCCAGAGCCTGTGCTGTGAGGGGCTTCGGGACCTTGGGGCAGCT
CCTGAGTTCAGACAGAGTTCAGGCAGGGAGACAGGGGCACAGAGAGACAGAGGTTCATGGACTG
AGGCAAAGGCTGGGCCCGGCTCAGCAACCCAGGCCTCCCGCAGGCAGGCAGAGGCTGCCCTGTA
ACCCACGCAGACCAGACCAACAGCTCTGATGAGCTCCACAGTGGCTGCAGCTGCGCCTGCAGCT
GGGGCTGCCTCCAGGAAGGAGTCTCCAGGCAGATGGGGCCTGGGGGAGGATCCCACAGGCGTGA
GCCCCTCGCTCCAGTGCCGCGTGTGCGGAGACAGCAGCAGCGGGAAGCACTATGGCATCTATGC
CTGCAACGGCTGCAGCGGCTTCTTCAAGAGGAGCGTACGGCGGAGGCTCATCTACAGGTGCCAG
GTGGGGGCAGGGATGTGCCCCGTGGACAAGGCCCACCGCAACCAATGCCAGGCCTGCCGGCTGA
AGAAGTGCCTGCAGGCGGGGATGAACCAGGACGCCGTGCAGAATGAGCGCCAGCCGCGAAGCAC
AGCCCAGGTCCGCCTGGACAGCATGGAGTCCAACACTGAGCCCCGGCCGGAGTCCCTGGTGGCT
CCCCCGGCCCCGGCAGGGCCCAGCCCACGGGGCCCCACACCCATGTCTGCAGCCAGAGCCCTGG
GCCACCACTTCATGGCCAGCCTTATAACAGCTGAAACCTGTGCTAAGCTGGAGCCAGAGGATGC
TGATGAGAATATTGATGTCACCAGCAATGACCCTGAGTTCCCCTCCTCTCCATACTCCTCTTCC
TCCCCCTGCGGCCTGGACAGCATCCATGAGACCTCGGCTCGCCTACTCTTCATGGCCGTCAAGT
GGGCCAAGAACCTGCCTGTGTTCTCCAGCCTGCCCTTCCGGGATCAGGTGATCCTGCTGGAAGA
GGCGTGGAGTGAACTCTTTCTCCTCGGGGCCATCCAGTGGTCTCTGCCTCTGGACAGCTGTCCT
CTGCTGGCACCGCCCGAGGCCTCTGCTGCCGGTGGTGCCCAGGGCCGGCTCACGCTGGCCAGCA
TGGAGACGCGTGTCCTGCGGGAAACTATCTCTCGGTTCCGGGCGTTGGCGGTGGACCCCACGGA
GTTCGCCTGCATGAAGGCCTTGGTCCTCTTCAAGCCAGAGACGCGGGGCCTGAAGGATCCTGAG
CACGTAGAGGCCTTGCAGGACCAGTCCCAAGTGATGCTGAGCCAGCACAGCAAGGCCCACCACC
CCAGCCAGCCCGTGAGGTTTGGGAAATTGCTCCTGCTCCTCCCGTCTTTGAGGTTTATCACTGC
GGAACGCATCGAGCTCCTCTTTTTCCGCAAGACCATAGGGAATACTCCAATGGAGAAGCTCCTT
TGTGATATGTTCAAAAACTAGTGGGGGTGGAGGTGAAATGTTTCCAAGCACTCTGGAAAACAAT
CTACTGAAACGAAACATTTGCCTGCTCTTTGCCCCAGCAATTCCTCTTAGGTGTGTGTACCCAG
CAGAAATGCCTACTGAAAGATATTGTAAAAATATTCATAGCAGCTTTATTCATAATAGCCCCAA
ACTGTATATTGATGGTAGGATGAATTAACAAATTGTGGTATATTCATATAATGAAAAATAATTT
AAAAAGAATGAATTACGGATACATGTGGCAACACAGGTAAACTTCACAGACATAAAAGTTGAAT
GAAAGAAGCCAGGCAGAAGTTCCATTTATGCAGAGTTCAGGAACAGGCAAGACTAATTGACAAT
AATAGAAGTTGGAATAGTGGTTACTTCTGGGTGGTGGGGGATTGATACAGAGGGGGCTCATGGG
AGCCCTCTGGTGTACCAGAAATGTTGATTTTGATCTGGGCAGTGGTTTCACAAATGTATTCATA
CGTAATAATTCATTGAGCTGTGCACTTTATTTTGTTAGACCTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003818594	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ABM54394	(Get FASTA)	NCBI Sequence Viewer
	ABM54395	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000039852
	ENSPPAP00000039852.1

RefSeq Acc Id:

XP_003818594 ⟸ XM_003818546

- UniProtKB:

A0A2R9CNL6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFK
RSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVRLDSME
SNTEPRPESLVAPPAPAGPSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSN
DPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLG
AIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLRETISRFRALAVDPTEFACMKALVL
FKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFR
KTIGNTPMEKLLCDMFKN

hide sequence

RefSeq Acc Id:

ENSPPAP00000039852 ⟸ ENSPPAT00000062764

Protein Domains

NR LBD Nuclear receptor

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042596	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000062764.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.565.10	UniProtKB/TrEMBL
	3.30.50.10	UniProtKB/TrEMBL
InterPro	NHR-like_dom_sf	UniProtKB/TrEMBL
	NR0B1/2	UniProtKB/TrEMBL
	Nucl_hrmn_rcpt_lig-bd	UniProtKB/TrEMBL
	Nuclear_hrmn_rcpt	UniProtKB/TrEMBL
	Retinoid-X_rcpt/HNF4	UniProtKB/TrEMBL
	Znf_hrmn_rcpt	UniProtKB/TrEMBL
	Znf_NHR/GATA	UniProtKB/TrEMBL
NCBI Gene	NR2E3	ENTREZGENE
PANTHER	NR LBD DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	NUCLEAR HORMONE RECEPTOR	UniProtKB/TrEMBL
	NUCLEAR RECEPTOR SUBFAMILY 0 GROUP B	UniProtKB/TrEMBL
	PHOTORECEPTOR-SPECIFIC NUCLEAR RECEPTOR	UniProtKB/TrEMBL
Pfam	Hormone_recep	UniProtKB/TrEMBL
	zf-C4	UniProtKB/TrEMBL
PRINTS	RETINOIDXR	UniProtKB/TrEMBL
	STRDHORMONER	UniProtKB/TrEMBL
	STROIDFINGER	UniProtKB/TrEMBL
PROSITE	NR_LBD	UniProtKB/TrEMBL
	NUCLEAR_REC_DBD_1	UniProtKB/TrEMBL
	NUCLEAR_REC_DBD_2	UniProtKB/TrEMBL
SMART	HOLI	UniProtKB/TrEMBL
	ZnF_C4	UniProtKB/TrEMBL
Superfamily-SCOP	Glucocorticoid receptor-like (DNA-binding domain)	UniProtKB/TrEMBL
	SSF48508	UniProtKB/TrEMBL
UniProt	A0A2R9CNL6	ENTREZGENE, UniProtKB/TrEMBL
	A1YGG9_PANPA	UniProtKB/TrEMBL
	A1YGH0_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

RGD Manual Annotations