CHMP4A (charged multivesicular body protein 4A)

Gene: CHMP4A (charged multivesicular body protein 4A) Pan paniscus

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Symbol:

CHMP4A

Name:

charged multivesicular body protein 4A

RGD ID:

11726518

Description:

ENCODES a protein that exhibits ATPase binding (ortholog); identical protein binding (ortholog); protein homodimerization activity (ortholog); INVOLVED IN autophagy (ortholog); membrane invagination (ortholog); nervous system process (ortholog); ASSOCIATED WITH Brain-Lung-Thyroid Syndrome (ortholog); lysinuric protein intolerance (ortholog); Specific Granule Deficiency (ortholog); FOUND IN cytoplasm (ortholog); endosome (ortholog); membrane coat (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,563,742 - 25,567,848 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,780,234 - 24,784,336 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	4,985,642 - 4,989,985 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,109,521 - 23,114,253 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain-Lung-Thyroid Syndrome (ISO)

lysinuric protein intolerance (ISO)

Specific Granule Deficiency (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

autophagosome maturation (IEA)

autophagy (ISO)

late endosome to lysosome transport (IEA)

late endosome to vacuole transport via multivesicular body sorting pathway (IEA)

membrane invagination (ISO)

midbody abscission (IEA)

mitotic metaphase chromosome alignment (IEA)

multivesicular body sorting pathway (IEA)

nervous system process (ISO)

nuclear membrane reassembly (IEA)

nucleus organization (ISO)

plasma membrane repair (IEA)

plasma membrane tubulation (ISO)

post-translational protein targeting to endoplasmic reticulum membrane (ISO)

protein localization to membrane (IEA)

protein polymerization (ISO)

regulation of mitotic spindle assembly (IEA)

ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (IEA)

vacuolar transport (IEA)

vesicle budding from membrane (IEA)

viral budding from plasma membrane (IEA)

viral budding via host ESCRT complex (IEA)

Cellular Component

amphisome membrane (IEA)

autophagosome membrane (IEA)

cytoplasm (ISO)

cytoplasmic side of plasma membrane (IEA)

endosome (ISO)

ESCRT III complex (IEA)

kinetochore (IEA)

kinetochore microtubule (IEA)

lysosomal membrane (IEA)

membrane (IEA)

membrane coat (ISO)

midbody (IEA)

multivesicular body (IEA)

multivesicular body membrane (IEA)

nuclear pore (IEA,ISO)

nucleus (ISO)

plasma membrane (ISO)

Molecular Function

ATPase binding (ISO)

identical protein binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

CHMP4A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	25,563,742 - 25,567,848 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	24,780,234 - 24,784,336 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	4,985,642 - 4,989,985 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	23,109,521 - 23,114,253 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

CHMP4A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	24,209,615 - 24,213,488 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	24,209,615 - 24,213,830 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	24,678,821 - 24,682,694 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	23,748,627 - 23,753,025 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	23,748,626 - 23,753,025	NCBI
Celera	14	4,543,256 - 4,547,822 (-)	NCBI		Celera
Cytogenetic Map	14	q12	NCBI
HuRef	14	4,793,794 - 4,798,040 (-)	NCBI		HuRef
CHM1_1	14	24,677,437 - 24,681,686 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	18,407,991 - 18,411,864 (-)	NCBI		T2T-CHM13v2.0

CHMP4A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	4,195,766 - 4,200,101 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	4,195,975 - 4,200,086 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	4,117,449 - 4,121,771 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	4,306,533 - 4,310,856 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	4,306,567 - 4,310,860 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	3,996,938 - 4,001,258 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	4,058,741 - 4,063,058 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	4,321,058 - 4,325,379 (-)	NCBI		UU_Cfam_GSD_1.0

Chmp4a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	36,044,063 - 36,048,021 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936722	341,307 - 345,104 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936722	341,066 - 344,928 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CHMP4A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	75,089,423 - 75,097,761 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	75,089,092 - 75,093,796 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	80,356,658 - 80,361,183 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CHMP4A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	1,192,581 - 1,196,989 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	1,192,842 - 1,197,742 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666036	12,876,430 - 12,881,383 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Chmp4a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624820	8,281,081 - 8,284,969 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008961253	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_008961253 ⟹ XP_008959501

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	25,563,742 - 25,567,848 (-)	NCBI
NHGRI_mPanPan1	14	24,780,234 - 24,784,336 (-)	NCBI
Mhudiblu_PPA_v0	14	4,985,642 - 4,989,985 (-)	NCBI
PanPan1.1	14	23,109,521 - 23,114,253 (-)	NCBI

Sequence:

show sequence

TTAGGGCAACCCCAAGTGCTTGAACCTATACCACCCCACTTTCCTGAGCTCTGTAAAGAGCATG
AAGTTTTCCCACTGACCCCATACACTGAGGTGCCATCACACTGCACATTTCCTTCCGGAGAACA
AGCACATACTCGGGTGGAGATAGAACTGTCTTTTTACTTAATACAAAATGATGTGGCAGCTTTA
AGAGGAGCGCGTCGGTCTGGGGCTGGTGGCTTGGGTCACGTGGCACCGGTGGTCTCGTTTGCGC
CTCCTGATGTCGCGGCGGCGCCCTGAGGACGGATTGGGCAAGGCTGGTCCCTGTGTGATGAGAC
ATCACCCTCCCAGGAGCAAGGCGGAAGTCTGGAGGACGCTGAGGGGCGGAGGCGGGAGAGGCGA
GCTCGCGATGAGTGGTCTCGGCAGGCTCTTCGGGAAGGGGAAGAAGGAGAAAGGGCCAACCCCT
GAAGAAGCAATACAGAAACTGAAGGAGACAGAGAAGATACTGATCAAGAAACAGGAATTTTTGG
AGCAGAAGATTCAACAGGAGCTACAAACAGCCAAGAAGTATGGGACCAAGAATAAGAGAGCTGC
CCTACAGGCTTTGCGGAGGAAGAAAAGATTCGAACAGCAGCTGGCACAAACTGACGGGACATTA
TCCACCCTGGAGTTTCAGCGTGAGGCCATTGAGAATGCCACTACCAATGCAGAAGTCCTTCGTA
CCATGGAGCTTGCTGCCCAAAGCATGAAGAAGGCCTACCAGGACATGGACATTGACAAGGTAGA
TGAACTGATGACTGACATCACGGAACAACAGGAGGTGGCCCAGCAGATCTCAGATGCCATTTCT
CGGCCTATGGGCTTTGGAGATGATGTGGATGAGGATGAACTGCTGGAGGAGCTAGAGGAGCTGG
AGCAGGAGGAATTGGCCCAGGAGTTGTTAAATGTGGGCGACAAGGAAGAAGAACCCCCAGTCAA
ATTGCCTAGTGTACCTTCTACTCATCTGCCGGCAGGGCCAGCTCCCAAAGTGGATGAAGATGAA
GAAGCACTAAAGCAGTTGGCTGAGTGGGTATCCTGATAAATCTGGGCTTGTCTTCCTAATGCTA
CCTTTGTTGGTCCTTTCTTCCTTAAGTGCCAAGTGCTGAGCTAAAGGAGGATAACTTTTTGGGG
AAGTCATGCTGAGGGTGGTAGTGTGACCCTGCCTGAAAAAAGGGTCTCTTACCCTCCCAGCCCT
GGCTCAACTCTGAAGAAGGATCTTGCTACAGAAGGAGCCCTTGGGCTACCTTCTCTTTGATAGC
AGTTATAATGCCCTTGTTCCCAATAAAACTGGGCAGATGGAATCCTAGTGTCTATACTGCCTTG
TCTACCCCTGAA

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Protein Sequences


Protein RefSeqs	XP_008959501	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000039517.1
	ENSPPAP00000039520
	ENSPPAP00000039520.1
	ENSPPAP00000039521.1

RefSeq Acc Id:

XP_008959501 ⟸ XM_008961253

- UniProtKB:

A0A2R9CC56 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSRRRPEDGLGKAGPCVMRHHPPRSKAEVWRTLRGGGGRGELAMSGLGRLFGKGKKEKGPTPEE
AIQKLKETEKILIKKQEFLEQKIQQELQTAKKYGTKNKRAALQALRRKKRFEQQLAQTDGTLST
LEFQREAIENATTNAEVLRTMELAAQSMKKAYQDMDIDKVDELMTDITEQQEVAQQISDAISRP
MGFGDDVDEDELLEELEELEQEELAQELLNVGDKEEEPPVKLPSVPSTHLPAGPAPKVDEDEEA
LKQLAEWVS

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Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042444	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000062428.1	UniProtKB/TrEMBL
	ENSPPAT00000062431.1	UniProtKB/TrEMBL
	ENSPPAT00000062432.1	UniProtKB/TrEMBL
Gene3D-CATH	6.10.250.1710	UniProtKB/TrEMBL
	ESAT-6-like	UniProtKB/TrEMBL
InterPro	EMP70	UniProtKB/TrEMBL
	Snf7_fam	UniProtKB/TrEMBL
KEGG Report	pps:103782671	UniProtKB/TrEMBL
NCBI Gene	CHMP4A	ENTREZGENE
PANTHER	CHARGED MULTIVESICULAR BODY PROTEIN 4A	UniProtKB/TrEMBL
	PTHR10766	UniProtKB/TrEMBL
	PTHR22761	UniProtKB/TrEMBL
	TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1	UniProtKB/TrEMBL
Pfam	EMP70	UniProtKB/TrEMBL
	Snf7	UniProtKB/TrEMBL
UniProt	A0A2R9CC56	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9CC62_PANPA	UniProtKB/TrEMBL
	A0A2R9CMY3_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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