BAP1 (BRCA1 associated protein 1) - Rat Genome Database

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Pathways
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Gene: BAP1 (BRCA1 associated protein 1) Pan paniscus
Analyze
Symbol: BAP1
Name: BRCA1 associated protein 1
RGD ID: 11687348
Description: ENCODES a protein that exhibits chromatin binding (inferred); chromatin DNA binding (inferred); cysteine-type deubiquitinase activity (inferred); INVOLVED IN macrophage homeostasis (ortholog); positive regulation of protein targeting to mitochondrion (ortholog); protein deubiquitination (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH adenoid cystic carcinoma (ortholog); adrenocortical carcinoma (ortholog); basal cell carcinoma (ortholog); FOUND IN PR-DUB complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ubiquitin carboxyl-terminal hydrolase BAP1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,396,300 - 52,405,519 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,401,975 - 52,410,291 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,344,067 - 52,352,187 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,573,785 - 53,581,943 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,573,785 - 53,581,943 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
adenoid cystic carcinoma  (ISO)
adrenocortical carcinoma  (ISO)
basal cell carcinoma  (ISO)
Bone Neoplasms  (ISO)
Breast Neoplasms  (ISO)
Central Nervous System Neoplasms  (ISO)
cholangiocarcinoma  (ISO)
clear cell renal cell carcinoma  (ISO)
Colonic Neoplasms  (ISO)
congenital diaphragmatic hernia  (ISO)
congenital disorder of glycosylation In  (ISO)
congenital myopathy 5  (ISO)
Ewing sarcoma  (ISO)
extrahepatic bile duct adenocarcinoma  (ISO)
familial melanoma  (ISO)
ganglioglioma  (ISO)
Genetic Predisposition to Disease  (ISO)
Head and Neck Neoplasms  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Kidney Neoplasms  (ISO)
KURY-ISIDOR SYNDROME  (ISO)
leukemia  (ISO)
lipoma  (ISO)
Liver Neoplasms  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (ISO)
malignant mesothelioma  (ISO)
malignant pleural mesothelioma  (ISO)
medulloblastoma  (ISO)
meningioma  (ISO)
Mesothelioma  (ISO)
mucoepidermoid carcinoma  (ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
Neurodevelopmental Disorders  (ISO)
neuroendocrine tumor  (ISO)
Nevi and Melanomas  (ISO)
Nevus, Epithelioid and Spindle Cell  (ISO)
ocular melanoma  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic cancer  (ISO)
paraganglioma  (ISO)
Prostatic Neoplasms  (ISO)
renal cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
Testicular Neoplasms  (ISO)
thymoma  (ISO)
Tumor Predisposition Syndrome  (ISO)
Tumor Predisposition Syndrome 1  (ISO)
urinary bladder cancer  (ISO)
Uterine Neoplasms  (ISO)
uveal melanoma  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)
PR-DUB complex  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
BAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2252,396,300 - 52,405,519 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1352,401,975 - 52,410,291 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0352,344,067 - 52,352,187 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,573,785 - 53,581,943 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,573,785 - 53,581,943 (-)Ensemblpanpan1.1panPan2
BAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38352,401,008 - 52,410,008 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl352,401,008 - 52,410,008 (-)EnsemblGRCh38hg38GRCh38
GRCh37352,435,024 - 52,444,024 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36352,410,064 - 52,419,049 (-)NCBINCBI36Build 36hg18NCBI36
Build 34352,410,066 - 52,419,049NCBI
Celera352,414,346 - 52,423,331 (-)NCBICelera
Cytogenetic Map3p21.1NCBI
HuRef352,497,655 - 52,506,755 (-)NCBIHuRef
CHM1_1352,387,546 - 52,396,647 (-)NCBICHM1_1
T2T-CHM13v2.0352,433,990 - 52,442,989 (-)NCBIT2T-CHM13v2.0
Bap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391430,973,358 - 30,981,887 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1430,973,407 - 30,981,901 (+)EnsemblGRCm39 Ensembl
GRCm381431,251,352 - 31,259,930 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1431,251,450 - 31,259,944 (+)EnsemblGRCm38mm10GRCm38
MGSCv371432,064,675 - 32,073,115 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361430,080,596 - 30,088,939 (+)NCBIMGSCv36mm8
Celera1427,510,099 - 27,518,539 (+)NCBICelera
Cytogenetic Map14BNCBI
cM Map1419.09NCBI
Bap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8166,453,126 - 6,461,952 (+)NCBIGRCr8
mRatBN7.2166,446,709 - 6,455,535 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl166,446,709 - 6,455,535 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx166,458,869 - 6,467,694 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0167,603,765 - 7,612,590 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0166,466,025 - 6,474,848 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0167,336,685 - 7,345,511 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl167,336,685 - 7,345,511 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0167,265,075 - 7,273,901 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4166,684,470 - 6,693,296 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1166,684,871 - 6,691,564 (+)NCBI
Celera168,733,498 - 8,742,324 (-)NCBICelera
Cytogenetic Map16p16NCBI
Bap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554302,390,524 - 2,400,645 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554302,391,970 - 2,400,645 (-)NCBIChiLan1.0ChiLan1.0
BAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,355,499 - 37,364,298 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,355,494 - 37,511,125 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,337,055 - 37,345,854 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02037,705,626 - 37,714,425 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2037,705,621 - 37,786,632 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,069,579 - 37,078,375 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,478,238 - 37,487,043 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02037,762,923 - 37,771,723 (+)NCBIUU_Cfam_GSD_1.0
Bap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118170,100,437 - 170,109,229 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364733,239,010 - 3,247,806 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364733,239,009 - 3,247,806 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,544,581 - 34,553,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,544,570 - 34,553,538 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,758,317 - 37,767,182 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,765,510 - 13,774,866 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2213,764,686 - 13,774,740 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041153,126,822 - 153,136,184 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248224,809,405 - 4,818,515 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248224,809,489 - 4,818,514 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000033433   ⟹   ENSPPAP00000010779
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl353,573,785 - 53,581,943 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000033438   ⟹   ENSPPAP00000010784
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl353,574,149 - 53,581,721 (-)Ensembl
RefSeq Acc Id: XM_003818761   ⟹   XP_003818809
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,396,300 - 52,405,519 (-)NCBI
NHGRI_mPanPan1352,401,975 - 52,410,291 (-)NCBI
Mhudiblu_PPA_v0352,344,067 - 52,352,111 (-)NCBI
PanPan1.1353,573,785 - 53,581,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014344234   ⟹   XP_014199720
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,396,300 - 52,405,519 (-)NCBI
NHGRI_mPanPan1352,401,975 - 52,410,291 (-)NCBI
Mhudiblu_PPA_v0352,344,067 - 52,352,177 (-)NCBI
PanPan1.1353,573,785 - 53,581,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034956601   ⟹   XP_034812492
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,396,300 - 52,403,292 (-)NCBI
NHGRI_mPanPan1352,401,975 - 52,408,064 (-)NCBI
Mhudiblu_PPA_v0352,344,067 - 52,350,157 (-)NCBI
RefSeq Acc Id: XM_063602404   ⟹   XP_063458474
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,396,300 - 52,405,329 (-)NCBI
RefSeq Acc Id: XM_063602405   ⟹   XP_063458475
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2252,396,300 - 52,405,243 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003818809   ⟸   XM_003818761
- Peptide Label: isoform X3
- UniProtKB: A0A2R9A4W5 (UniProtKB/TrEMBL),   A0A2R9A4W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014199720   ⟸   XM_014344234
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A4W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034812492   ⟸   XM_034956601
- Peptide Label: isoform X5
RefSeq Acc Id: ENSPPAP00000010784   ⟸   ENSPPAT00000033438
RefSeq Acc Id: ENSPPAP00000010779   ⟸   ENSPPAT00000033433
RefSeq Acc Id: XP_063458474   ⟸   XM_063602404
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063458475   ⟸   XM_063602405
- Peptide Label: isoform X4
Protein Domains
Peptidase C12 C-terminal   Ubiquitin carboxyl-terminal hydrolase family


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028588 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000033433.1 UniProtKB/TrEMBL
  ENSPPAT00000033438.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.58.860 UniProtKB/TrEMBL
  3.40.532.10 UniProtKB/TrEMBL
InterPro Papain-like_cys_pep_sf UniProtKB/TrEMBL
  Peptidase_C12_UCH UniProtKB/TrEMBL
  Peptidase_C12_UCH_sf UniProtKB/TrEMBL
  UCH_C UniProtKB/TrEMBL
KEGG Report pps:100985439 UniProtKB/TrEMBL
NCBI Gene BAP1 ENTREZGENE
PANTHER PTHR10589 UniProtKB/TrEMBL
  UBIQUITIN CARBOXYL-TERMINAL HYDROLASE BAP1 UniProtKB/TrEMBL
Pfam Peptidase_C12 UniProtKB/TrEMBL
  UCH_C UniProtKB/TrEMBL
PRINTS UBCTHYDRLASE UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A2R9A4W5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A4W9 ENTREZGENE, UniProtKB/TrEMBL