CVCL_JG97 - Rat Genome Database

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Cell Line : CVCL_JG97 (POLK KO-POLH-/-) Homo sapiens

Symbol: CVCL_JG97
Name: POLK KO-POLH-/-
RGD ID: 21118532
Cell Line Type: cancer cell line
Origin: Population: Caucasian; Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Gender: Male
Genomic Alteration: Knockout cell: Method=Homologous recombination; HGNC; 9181; POLH; Knockout cell: Method=Homologous recombination; HGNC; 9183; POLK; Knockout cell: Method=Homologous recombination; HGNC; 11830; TK1 (Note=1 of 2 alleles); Sequence variation: Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line); Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line); Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line); Sequence variation: Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line); Transfected with: HGNC; 7325; MSH2 (exons 9 to 16)
Related Genes: MSH2   POLH   POLK   TK1  
Derived From Cell Lines: CVCL_UD71 (Nalm-6-MSH+/TK+/-)
Aliases: Nalm-6-MSH+/TK+/-/POLH-/-/POLK-/-
Disease(s): B-cell adult acute lymphocytic leukemia (DOID:0060592) [NCI:C9143]

References

Additional Information

Database Acc Id Source(s)
cancercelllines CVCL_JG97 CELLOSAURUS
Cellosaurus CVCL_JG97 CELLOSAURUS
JCRB JCRB1530 CELLOSAURUS
NCIt C9143 CELLOSAURUS
Orphanet 99860 CELLOSAURUS
Wikidata Q54947733 CELLOSAURUS