Cell Line : CVCL_RA34 (Nalm6-Fluc-Neo/eGFP-Puro) Homo sapiens
Symbol:	CVCL_RA34
Name:	Nalm6-Fluc-Neo/eGFP-Puro
RGD ID:	21108921
Cell Line Type:	cancer cell line
Origin:	Population: Caucasian; Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Gender:	Male
Characteristics:	Characteristics: Reporter cell line, transfected with both the LV-Fluc-P2A-Neo and LV-eGFP-PGK-Puro vectors LV-Fluc-P2A-Neo encodes for luciferase linked via a P2A cleavage peptide to the neo gene and under control of the spleen focus-forming virus (SFFV) promoter. LV-eGFP-PGK-Puro encodes for eGFP under control of the spleen focus-forming virus (SFFV) promoter and the pac gene under the control of the mouse PGK promoter.
Genomic Alteration:	Sequence variation: Gene fusion; HGNC; 50800; DUX4 + HGNC; 5477; IGH; Name(s)=IGH-DUX4; Note=The translocation occurs in the silenced IGH allele (from parent cell line); Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Arg1068Ter (c.3202C>T); Zygosity=Heterozygous (from parent cell line); Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Ala146Thr (c.436G>A); Zygosity=Heterozygous (from parent cell line); Sequence variation: Mutation; HGNC; 9864; RARA; Simple; p.Gln45Ter (c.133C>T); ClinVar=VCV000393019; Zygosity=Heterozygous (from parent cell line); Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP); Transfected with: UniProtKB; P08659; Firefly luciferase; Transfected with: UniProtKB; P00552; Transposon Tn5 neo; Transfected with: UniProtKB; P13249; S.alboniger pac (PuroR)
Derived From Cell Lines:	CVCL_0092 (NALM-6)
Disease(s):	B-cell adult acute lymphocytic leukemia (DOID:0060592) [NCI:C9143]

External Database Links

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Database	Acc Id	Source(s)
cancercelllines	CVCL_RA34	CELLOSAURUS
Cellosaurus	CVCL_RA34	CELLOSAURUS
NCIt	C9143	CELLOSAURUS
Orphanet	99860	CELLOSAURUS
Wikidata	Q54907443	CELLOSAURUS

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