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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621320
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:9381
Term: T-2 toxin
Definition: A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionEXP 6480464CTDT-2 Toxin results in increased expression of MMP9 mRNAPMID:29079362
Mmp9multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased expression of MMP9 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [T-2 Toxin results in increased expression of MMP9 mRNA]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [T-2 Toxin results in increased expression of MMP9 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in increased expression of MMP9 mRNA]; SB 203580 inhibits the reaction [T-2 Toxin results in increased expression of MMP9 mRNA]PMID:29079362
Mmp9affects expressionISOMmp9 (Mus musculus)6480464CTDT-2 Toxin affects the expression of MMP9 mRNAPMID:22960706
Mmp9increases activityISOMmp9 (Mus musculus)6480464CTDT-2 Toxin results in increased activity of MMP9 proteinPMID:21112371
Mmp9increases expressionISOMmp9 (Mus musculus)6480464CTDT-2 Toxin results in increased expression of MMP9 mRNAPMID:21112371 PMID:22800716
Mmp9multiple interactionsISOMmp9 (Mus musculus)6480464CTDT-2 Toxin results in increased expression of and results in increased activity of MMP9 proteinPMID:22960706
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