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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314001
Species: Homo sapiens
RGD Object: Gene
Symbol: PINK1
Name: PTEN induced kinase 1
Acc ID: CHEBI:9381
Term: T-2 toxin
Definition: A trichothecene mycotoxin produced by fungi of the genus Fusarium. It is a common contaminant in food and feedstuffs of cereal origin and is known to cause a range of toxic effects in humans and animals.
Chemical ID: MESH:D013605
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PINK1increases expressionISOPink1 (Rattus norvegicus)6480464CTDT-2 Toxin results in increased expression of PINK1 mRNA; T-2 Toxin results in increased expression of PINK1 proteinPMID:29870751
PINK1multiple interactionsISOPink1 (Rattus norvegicus)6480464CTDN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [T-2 Toxin results in increased expression of PINK1 protein]; NFE2L2 protein affects the reaction [T-2 Toxin results in increased expression of PINK1 protein]; PINK1 promotes the reaction [T-2 Toxin results in increased expression of DNM1L mRNA]; PINK1 promotes the reaction [T-2 Toxin results in increased expression of FIS1 mRNA]; PINK1 promotes the reaction [T-2 Toxin results in increased expression of MFN1 mRNA]; PINK1 promotes the reaction [T-2 Toxin results in increased expression of OPA1 mRNA]PMID:29870751 PMID:36863559
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