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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61867
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp9
Name: caspase 9
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Casp9decreases expressionEXP 6480464CTDStreptozocin results in decreased expression of CASP9 proteinPMID:34455488
Casp9increases activityEXP 6480464CTDStreptozocin results in increased activity of CASP9 proteinPMID:22940631 PMID:29606028
Casp9increases expressionEXP 6480464CTDStreptozocin results in increased expression of CASP9 mRNA; Streptozocin results in increased expression of CASP9 proteinPMID:19951573 PMID:26614261 PMID:28856781 PMID:36462176
Casp9multiple interactionsEXP 6480464CTDAnthocyanins inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]; IGF2R protein modified form inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]; Insulin promotes the reaction [Ozone inhibits the reaction [Streptozocin results in increased expression of CASP9 mRNA]]; nifuroxazide inhibits the reaction [Streptozocin results in increased activity of CASP9 protein]; Ozone inhibits the reaction [Streptozocin results in increased expression of CASP9 mRNA]; Phosphocreatine inhibits the reaction [Streptozocin results in decreased expression of CASP9 protein]; Streptozocin results in increased expression of and results in increased cleavage of CASP9 protein; Thioctic Acid inhibits the reaction [Streptozocin results in increased expression of CASP9 protein]PMID:15976052 PMID:19951573 PMID:26614261 PMID:28856781 PMID:29606028 PMID:34455488 PMID:36462176
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