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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308314
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:9130
Term: sevoflurane
Definition: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Chemical ID: MESH:C009250
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3increases expressionEXP 6480464CTDSevoflurane results in increased expression of NLRP3 proteinPMID:36047109 PMID:36155068
Nlrp3multiple interactionsEXP 6480464CTDPHLDA1 protein promotes the reaction [Sevoflurane results in increased expression of NLRP3 protein]; WDR48 protein affects the reaction [Sevoflurane results in increased expression of NLRP3 protein]PMID:36047109 PMID:36155068
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