Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [methylmercuric chloride results in increased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of SQSTM1 protein]PMID:27667695 PMID:33684387
Sqstm1decreases expressionISOSQSTM1 (Homo sapiens)6480464CTDpyrazolanthrone results in decreased expression of SQSTM1 proteinPMID:27393035
Sqstm1increases expressionISOSqstm1 (Rattus norvegicus)6480464CTDpyrazolanthrone results in increased expression of SQSTM1 proteinPMID:24833599
Sqstm1multiple interactionsISOSqstm1 (Rattus norvegicus)6480464CTDpyrazolanthrone inhibits the reaction [Colistin results in increased degradation of SQSTM1 protein]PMID:28842171
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTDpyrazolanthrone affects the reaction [sodium arsenite affects the expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [morusin results in decreased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]]; pyrazolanthrone inhibits the reaction [pachastrissamine analog results in increased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [Quercetin results in increased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [tetrachlorobenzoquinone results in increased expression of SQSTM1 protein]PMID:25881548 PMID:27393035 PMID:33035517 PMID:34861471 PMID:35123989
Go Back to source page   Continue to Ontology report