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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318015
Species: Mus musculus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:8890
Term: (S)-ropivacaine
Definition: A piperidinecarboxamide-based amide-type local anaesthetic (amide caine) in which (S)-N-propylpipecolic acid and 2,6-dimethylaniline are combined to form the amide bond.
Chemical ID: MESH:C037663
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3increases expressionISONLRP3 (Homo sapiens)6480464CTDRopivacaine results in increased expression of NLRP3 proteinPMID:36858639
Nlrp3multiple interactionsISONLRP3 (Homo sapiens)6480464CTDDexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine inhibits the reaction [Ropivacaine results in increased expression of NLRP3 protein]]PMID:36858639
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