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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2909
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kpnb1
Name: karyopherin subunit beta 1
Acc ID: CHEBI:8249
Term: piroxicam
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-hydroxy-2-methyl-2H-1,2-benzothiazine-3-carboxylic acid 1,1-dioxide with the exocyclic nitrogen of 2-aminopyridine. A non-steroidal anti-inflammatory drug of the oxicam class, it is used to relieve pain and works by preventing the production of endogenous prostaglandins involved in the mediation of pain, stiffness, tenderness and swelling.
Chemical ID: MESH:D010894
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kpnb1decreases expressionISOKPNB1 (Homo sapiens)6480464CTDPiroxicam results in decreased expression of KPNB1 mRNAPMID:21858171
Kpnb1multiple interactionsISOKPNB1 (Homo sapiens)6480464CTDCisplatin affects the reaction [Piroxicam results in decreased expression of KPNB1 mRNA]PMID:21858171
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