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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1multiple interactionsEXP 6480464CTDdiallyl trisulfide inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased expression of SQSTM1 protein]PMID:36796188
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDdiallyl trisulfide results in increased expression of SQSTM1 mRNAPMID:34887701 PMID:34995734
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