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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:77319
Term: oltipraz
Definition: A 1,2-dithiole that is 3H-1,2-dithiole-3-thione substituted at positions 4 and 5 by methyl and pyrazin-2-yl groups respectively.
Chemical ID: MESH:C026209
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2increases expressionEXP 6480464CTDoltipraz results in increased expression of ABCC2 mRNA; oltipraz results in increased expression of ABCC2 proteinPMID:12920174
Abcc2increases expressionISOAbcc2 (Mus musculus)6480464CTDoltipraz results in increased expression of ABCC2 mRNAPMID:15833929
Abcc2increases expressionISOABCC2 (Homo sapiens)6480464CTDoltipraz results in increased expression of ABCC2 mRNA; oltipraz results in increased expression of ABCC2 proteinPMID:16837569 PMID:25752797 PMID:34678219
Abcc2multiple interactionsISOAbcc2 (Mus musculus)6480464CTD[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC2 protein; [oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of ABCC2 mRNAPMID:15833929 PMID:18032408
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