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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1305471
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf6
Name: activating transcription factor 6
Acc ID: CHEBI:7496
Term: nelfinavir
Definition: An aryl sulfide that is used (as its mesylate salt) for treatment of HIV and also exhibits some anticancer properties.
Chemical ID: MESH:D019888
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf6affects localizationISOATF6 (Homo sapiens)6480464CTDNelfinavir affects the localization of ATF6 proteinPMID:21355074
Atf6decreases cleavageISOATF6 (Homo sapiens)6480464CTDNelfinavir results in decreased cleavage of ATF6 proteinPMID:21355074
Atf6decreases expressionISOATF6 (Homo sapiens)6480464CTDNelfinavir results in decreased expression of ATF6 protein alternative formPMID:21355074
Atf6increases stabilityISOATF6 (Homo sapiens)6480464CTDNelfinavir results in increased stability of ATF6 proteinPMID:21355074
Atf6multiple interactionsISOATF6 (Homo sapiens)6480464CTDNelfinavir inhibits the reaction [MBTPS2 protein results in increased cleavage of and results in increased activity of ATF6 protein]PMID:21355074
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