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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:72564
Term: temozolomide
Definition: An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical ID: MESH:C047246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1adecreases expressionISOCDKN1A (Homo sapiens)6480464CTDTemozolomide results in decreased expression of CDKN1A mRNAPMID:31758290
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDtemozolomide results in increased expression of CDKN1A proteinPMID:16193384
Cdkn1amultiple interactionsISOCdkn1a (Mus musculus)6480464CTD[temozolomide co-treated with O(6)-benzylguanine] results in increased expression of CDKN1A protein; TRP53 protein affects the reaction [[temozolomide co-treated with O(6)-benzylguanine] results in increased expression of CDKN1A protein]PMID:20980775
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[temozolomide co-treated with O(6)-benzylguanine] affects the localization of CDKN1A protein; [temozolomide co-treated with O(6)-benzylguanine] results in increased expression of CDKN1A proteinPMID:20980775
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