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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308118
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sh3bgrl3
Name: SH3 domain binding glutamate-rich protein like 3
Acc ID: CHEBI:72564
Term: temozolomide
Definition: An imidazotetrazine that is 3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine which is substituted at positions 3, 4, and 8 by methyl, oxo, and carboxamide groups, respectively. A prodrug for MTIC (5-(3-methyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide, formed by spontaneous hydrolysis of temozolomide in the body), it is used as an oral alkylating agent for the treatment of newly diagnosed malignant glioblastoma multiforme (concomitantly with radiotherapy) and malignant melanoma.
Chemical ID: MESH:C047246
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sh3bgrl3decreases expressionISOSH3BGRL3 (Homo sapiens)6480464CTDTemozolomide results in decreased expression of SH3BGRL3 mRNAPMID:31758290
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