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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:7005
Term: morusin
Definition: An extended flavonoid that is flavone substituted by hydroxy groups at positions 5, 2' and 4', a prenyl group at position 3 and a 2,2-dimethyl pyran group across positions 7 and 8.
Chemical ID: MESH:C057451
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1decreases expressionISOSQSTM1 (Homo sapiens)6480464CTDmorusin results in decreased expression of SQSTM1 proteinPMID:33035517
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDmorusin results in increased expression of SQSTM1 proteinPMID:29421517
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid inhibits the reaction [morusin results in increased expression of SQSTM1 protein]; pyrazolanthrone inhibits the reaction [morusin results in decreased expression of SQSTM1 protein]; U 0126 inhibits the reaction [morusin results in decreased expression of SQSTM1 protein]PMID:29421517 PMID:33035517
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