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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:6842
Term: methoxychlor
Definition: An organochlorine insecticide that has formula C16H15Cl3O2.
Chemical ID: MESH:D008731
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6decreases activityEXP 6480464CTDMethoxychlor results in decreased activity of CYP2B6 proteinPMID:9241656
CYP2B6decreases methylationEXP 6480464CTDCYP2B6 protein results in decreased methylation of MethoxychlorPMID:12167570 PMID:12433799 PMID:9733665
CYP2B6increases activityEXP 6480464CTDMethoxychlor results in increased activity of CYP2B6 proteinPMID:24832206
CYP2B6increases expressionEXP 6480464CTDMethoxychlor results in increased expression of CYP2B6 mRNA; Methoxychlor results in increased expression of CYP2B6 proteinPMID:15548381 PMID:21924250 PMID:24832206
CYP2B6increases hydroxylationEXP 6480464CTDCYP2B6 protein results in increased hydroxylation of MethoxychlorPMID:10101147 PMID:7895613 PMID:9047321
CYP2B6increases metabolic processingEXP 6480464CTDCYP2B6 protein results in increased metabolism of MethoxychlorPMID:12464242
CYP2B6multiple interactionsEXP 6480464CTD[Endosulfan co-treated with Methoxychlor] results in decreased activity of CYP2B6 protein; Methoxychlor inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]; Methoxychlor inhibits the reaction [CYP2B6 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]; Methoxychlor inhibits the reaction [CYP2B6 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin]PMID:10037683 PMID:24832206 PMID:9241656
CYP2B6decreases activityISOCyp2b10 (Mus musculus)6480464CTDMethoxychlor results in decreased activity of CYP2B10 proteinPMID:18420780
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