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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708428
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Akr1c3
Name: aldo-keto reductase family 1, member C3
Acc ID: CHEBI:6716
Term: medroxyprogesterone acetate
Definition: An acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control.
Chemical ID: MESH:D017258
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1c3decreases activityISOAKR1C3 (Homo sapiens)6480464CTDMedroxyprogesterone Acetate results in decreased activity of AKR1C3 proteinPMID:12604236 PMID:19997560 PMID:21182831 PMID:23261716
Akr1c3multiple interactionsISOAKR1C3 (Homo sapiens)6480464CTD[Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein co-treated with NADP] results in increased reduction of cyclopentanone]; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]PMID:19997560 PMID:23261716
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