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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346235
Species: Homo sapiens
RGD Object: Gene
Symbol: NFATC1
Name: nuclear factor of activated T cells 1
Acc ID: CHEBI:66331
Term: xanthohumol
Definition: A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4', a methoxy group at position 6' and a prenyl group at position 3'. Isolated from Humulus lupulus, it induces apoptosis in human malignant glioblastoma cells.
Chemical ID: MESH:C104536
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFATC1multiple interactionsISONfatc1 (Mus musculus)6480464CTDxanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]PMID:23994090
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