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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359580
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atg5
Name: autophagy related 5
Acc ID: CHEBI:6432
Term: levamisole
Definition: A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine.
Chemical ID: MESH:D007978
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atg5multiple interactionsISOAtg5 (Mus musculus)6480464CTDLevamisole inhibits the reaction [Cyclophosphamide results in decreased expression of ATG5 protein]PMID:32151603
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