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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62109
Species: Mus musculus
RGD Object: Gene
Symbol: Col1a1
Name: collagen, type I, alpha 1
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col1a1increases expression ISOCol1a1 (Rattus norvegicus)156430318RGDisoprenaline increases expression of Col1a1 protein in blood serum  
Col1a1increases expressionEXP 6480464CTDIsoproterenol results in increased expression of COL1A1 mRNA; Isoproterenol results in increased expression of COL1A1 proteinPMID:31009642 PMID:31712309 PMID:37269933
Col1a1multiple interactionsEXP 6480464CTDBMP10 protein inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]; celastrol methyl ester inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; plantamajoside inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; Valsartan inhibits the reaction [Isoproterenol results in increased expression of COL1A1 protein]PMID:31009642 PMID:31712309 PMID:37269933
Col1a1increases expressionISOCol1a1 (Rattus norvegicus)6480464CTDIsoproterenol results in increased expression of COL1A1 mRNA; Isoproterenol results in increased expression of COL1A1 proteinPMID:24945829 PMID:26692091 PMID:28526319 PMID:35014750 PMID:9559417
Col1a1multiple interactionsISOCol1a1 (Rattus norvegicus)6480464CTDmanidipine inhibits the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]; MIR214 mRNA promotes the reaction [Isoproterenol results in increased expression of COL1A1 mRNA]PMID:26692091 PMID:9559417
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