GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sqstm1 | increases expression | EXP | | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in increased expression of SQSTM1 protein | PMID:30165626 | Sqstm1 | multiple interactions | EXP | | 6480464 | CTD | Chir 99021 inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SQSTM1 protein]; Imatinib Mesylate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SQSTM1 protein] | PMID:30165626 | Sqstm1 | decreases expression | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in decreased expression of SQSTM1 protein | PMID:36078115 | Sqstm1 | increases expression | ISO | Sqstm1 (Rattus norvegicus) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium results in increased expression of SQSTM1 mRNA; 1-Methyl-4-phenylpyridinium results in increased expression of SQSTM1 protein | PMID:28801915 PMID:30165626 | Sqstm1 | multiple interactions | ISO | Sqstm1 (Rattus norvegicus) | 6480464 | CTD | Imatinib Mesylate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of SQSTM1 protein] | PMID:30165626 | Sqstm1 | multiple interactions | ISO | SQSTM1 (Homo sapiens) | 6480464 | CTD | 1-Methyl-4-phenylpyridinium promotes the reaction [SQSTM1 protein binds to and results in decreased activity of SQSTM1 protein]; Chloroquine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SQSTM1 protein] | PMID:26409479 PMID:36078115 | | ||||||||||||||||||||||
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