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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1multiple interactionsEXP 6480464CTD[manganese chloride results in increased abundance of Manganese] which results in increased expression of SQSTM1 protein; Sirolimus inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of SQSTM1 protein]; SQSTM1 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of SQSTM1 protein]PMID:31690173
Sqstm1affects expressionISOSQSTM1 (Homo sapiens)6480464CTDmanganese chloride affects the expression of SQSTM1 proteinPMID:30578841
Sqstm1increases expressionISOSqstm1 (Rattus norvegicus)6480464CTDmanganese chloride results in increased expression of SQSTM1 proteinPMID:29222055
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDmanganese chloride results in increased expression of SQSTM1 proteinPMID:30672645
Sqstm1multiple interactionsISOSqstm1 (Rattus norvegicus)6480464CTDAcetylcysteine promotes the reaction [manganese chloride results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [manganese chloride results in increased expression of SQSTM1 protein]; resveratrol promotes the reaction [manganese chloride results in increased expression of SQSTM1 protein]; Sirolimus inhibits the reaction [manganese chloride results in increased expression of SQSTM1 protein]PMID:29222055
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD[N-((3-(aminomethyl)phenyl)methyl)ethanimidamide co-treated with manganese chloride] results in decreased expression of SQSTM1 protein; corynoxine B affects the reaction [manganese chloride affects the expression of SQSTM1 protein]PMID:28856835 PMID:30578841
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