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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Yy1
Name: YY1 transcription factor
Acc ID: CHEBI:63041
Term: manganese(II) chloride
Definition: An inorganic chloride in which manganese(II) is coordinated to two chloride ions. In its anhydrous state manganese(II) chloride is a polymeric solid, which adopts a layered cadmium chloride-like structure.
Chemical ID: MESH:C025340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Yy1multiple interactionsISOYY1 (Homo sapiens)6480464CTD[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]; [manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]; [manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; Acetylcysteine inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein]; IkK-16 compound inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 mRNA]; IkK-16 compound inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of YY1 protein]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to SLC1A2 promoter]]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of and affects the localization of YY1 protein]PMID:34310962 PMID:34800614
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