Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	736485
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Sqstm1
Name:	sequestosome 1

Acc ID:	CHEBI:5801
Term:	hydroxychloroquine
Definition:	An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Chemical ID:	MESH:D006886

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Sqstm1	increases expression	EXP		6480464	CTD	Hydroxychloroquine results in increased expression of SQSTM1 protein	PMID:32773031
Sqstm1	multiple interactions	EXP		6480464	CTD	[Dronabinol co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein; [HU 211 co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein	PMID:32773031
Sqstm1	increases expression	ISO	SQSTM1 (Homo sapiens)	6480464	CTD	Hydroxychloroquine results in increased expression of SQSTM1 protein	PMID:29426000
Sqstm1	multiple interactions	ISO	SQSTM1 (Homo sapiens)	6480464	CTD	Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]	PMID:29426000

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