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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730951
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS2
Name: nitric oxide synthase 2
Acc ID: CHEBI:53063
Term: 2,4,6-trinitrobenzenesulfonic acid
Definition: The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D014302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS2affects response to substanceISONos2 (Mus musculus)6480464CTDNOS2 protein affects the susceptibility to Trinitrobenzenesulfonic AcidPMID:17449036
NOS2increases activityISONos2 (Rattus norvegicus)6480464CTDTrinitrobenzenesulfonic Acid results in increased activity of NOS2 proteinPMID:31428839
NOS2increases expressionISONos2 (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA; Trinitrobenzenesulfonic Acid results in increased expression of NOS2 proteinPMID:11717450 PMID:17982090 PMID:19238344 PMID:19285099 PMID:20923188
NOS2increases expressionISONos2 (Rattus norvegicus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA; Trinitrobenzenesulfonic Acid results in increased expression of NOS2 proteinPMID:10845656 PMID:11504810 PMID:11698051 PMID:15867298 PMID:17276891 PMID:17375077 PMID:21893697 PMID:22039321 PMID:24831514 PMID:30365937 PMID:30503585
NOS2multiple interactionsISONos2 (Mus musculus)6480464CTDMinocycline inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]; NOS2 gene mutant form inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of CCN4 mRNA]; seryl-leucyl-isoleucyl-glycyl--arginyl-leucinamide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]; soyasaponin I inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]PMID:11717450 PMID:19238344 PMID:19285099 PMID:20923188
NOS2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDAlendronate affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Ampicillin inhibits the reaction [Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]]; Ampicillin inhibits the reaction [Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]]; Aspirin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]; bergenin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Celecoxib promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]; Hydroxamic Acids analog promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]; kappa-casein glycomacropeptide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]; montelukast inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; nitroaspirin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]; Sulfasalazine affects the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of NOS2 protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 protein]; Sulfur Dioxide inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of NOS2 mRNA]PMID:11698051 PMID:15867298 PMID:17375077 PMID:21893697 PMID:22039321 PMID:24831514 PMID:30365937 PMID:30503585 PMID:31428839
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