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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70373
Species: Homo sapiens
RGD Object: Gene
Symbol: BAX
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:53063
Term: 2,4,6-trinitrobenzenesulfonic acid
Definition: The arenesulfonic acid that is benzenesulfonic acid with three nitro substituents in the 2-, 4- and 6-positions.
Chemical ID: MESH:D014302
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BAXincreases expressionISOBax (Mus musculus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of BAX proteinPMID:22427801
BAXincreases expressionISOBax (Rattus norvegicus)6480464CTDTrinitrobenzenesulfonic Acid results in increased expression of BAX mRNA; Trinitrobenzenesulfonic Acid results in increased expression of BAX proteinPMID:15502641 PMID:24831514 PMID:31428839 PMID:33412153
BAXmultiple interactionsISOBax (Mus musculus)6480464CTDD-JNKI-1 inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of BAX protein]PMID:22427801
BAXmultiple interactionsISOBax (Rattus norvegicus)6480464CTDdapagliflozin promotes the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]; Losartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA]; Methylene Blue inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]; Sulfasalazine inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX protein]; Telmisartan inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of BAX mRNA]PMID:15502641 PMID:24831514 PMID:31428839 PMID:33412153
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