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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317960
Species: Mus musculus
RGD Object: Gene
Symbol: Akr1b10
Name: aldo-keto reductase family 1, member B10
Acc ID: CHEBI:50867
Term: ciprofibrate
Definition: A cyclopropane that has formula C13H14Cl2O3.
Chemical ID: MESH:C019304
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Akr1b10decreases activityISOAKR1B10 (Homo sapiens)6480464CTDciprofibrate results in decreased activity of AKR1B10 protein; ciprofibrate results in decreased activity of AKR1B10 protein mutant formPMID:18325492
Akr1b10multiple interactionsISOAKR1B10 (Homo sapiens)6480464CTDciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin]; ciprofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]PMID:19028477
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