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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621316
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:50694
Term: minocycline
Definition: A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
Chemical ID: MESH:D008911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases activityEXP 6480464CTDMinocycline results in decreased activity of MMP2 proteinPMID:16846501
Mmp2decreases expressionEXP 6480464CTDMinocycline results in decreased expression of MMP2 proteinPMID:11835378 PMID:16846501
Mmp2decreases expressionISOMMP2 (Homo sapiens)6480464CTDMinocycline results in decreased expression of MMP2 proteinPMID:14508231
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDMinocycline inhibits the reaction [Oxygen deficiency results in increased expression of MMP2 mRNA]PMID:24292262
Mmp2multiple interactionsISOMmp2 (Mus musculus)6480464CTDMinocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 mRNA]; Minocycline inhibits the reaction [Dextran Sulfate results in increased expression of MMP2 protein]PMID:19285099
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