Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731748
Species: Homo sapiens
RGD Object: Gene
Symbol: JAK2
Name: Janus kinase 2
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
JAK2decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of JAK2 proteinPMID:11721366 PMID:36352148
JAK2decreases phosphorylationEXP 6480464CTDArsenic Trioxide results in decreased phosphorylation of JAK2 proteinPMID:29409467
JAK2increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of JAK2 mRNAPMID:29633893
JAK2multiple interactionsEXP 6480464CTD[ruxolitinib co-treated with Arsenic Trioxide] results in decreased phosphorylation of JAK2 protein; Arsenic Trioxide inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]; Arsenic Trioxide promotes the reaction [Curcumin results in decreased expression of JAK2 protein]; pervanadate inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of JAK2 protein]; PTPN6 protein affects the reaction [Arsenic Trioxide results in decreased phosphorylation of JAK2 protein]PMID:12492118 PMID:29409467 PMID:30012499 PMID:36352148
Go Back to source page   Continue to Ontology report