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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628714
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd86
Name: CD86 molecule
Acc ID: CHEBI:4917
Term: eugenol
Definition: A phenylpropanoid formally derived from guaiacol with an allyl chain substituted para to the hydroxy group. It is a major component of clove essential oil, and exhibits antibacterial, analgesic and antioxidant properties. It has been widely used in dentistry to treat toothache and pulpitis.
Chemical ID: MESH:D005054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd86increases expressionISOCD86 (Homo sapiens)6480464CTDEugenol results in increased expression of CD86 proteinPMID:12423654 PMID:20488241 PMID:21742781 PMID:23624239 PMID:30806763
Cd86multiple interactionsISOCD86 (Homo sapiens)6480464CTD[Dicumarol results in decreased activity of NQO1 protein] inhibits the reaction [Eugenol results in increased expression of CD86 protein]PMID:21742781
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