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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1560766
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pid1
Name: phosphotyrosine interaction domain containing 1
Acc ID: CHEBI:4877
Term: ethambutol
Definition: An ethylenediamine derivative that is ethane-1,2-diamine in which one hydrogen attached to each of the nitrogens is sutstituted by a 1-hydroxybutan-2-yl group (S,S-configuration). It is a bacteriostatic antimycobacterial drug, effective against Mycobacterium tuberculosis and some other mycobacteria. It is used (as the dihydrochloride salt) in combination with other antituberculous drugs in the treatment of pulmonary and extrapulmonary tuberculosis; resistant strains of M. tuberculosis are readily produced if ethambutol is used alone.
Chemical ID: MESH:D004977
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pid1increases expressionISOPID1 (Homo sapiens)6480464CTDEthambutol results in increased expression of PID1 mRNAPMID:32816093
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