GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Chrna4 | affects binding | EXP | | 2303194 | RGD | Epibatidine binds to Chrna4 protein | | Chrna4 | affects binding | EXP | | 2303195 | RGD | epibatidine binds to Chrnb4 protein in the rat retina | | Chrna4 | affects binding | EXP | | 6480464 | CTD | epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein] | PMID:11124396 PMID:15615518 PMID:21942635 | Chrna4 | multiple interactions | EXP | | 6480464 | CTD | 2-(1'-methyl-2'-pyrrolidinyl)-7-hydroxy-1,4-benzodioxane inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; epibatidine binds to [CHRNA4 protein co-treated with CHRNB2 protein]; epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; sazetidine-A analog inhibits the reaction [epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]] | PMID:10728888 PMID:21905669 PMID:21942635 | Chrna4 | affects binding | ISO | Chrna4 (Mus musculus) | 6480464 | CTD | epibatidine binds to CHRNA4 protein | PMID:17203487 | Chrna4 | affects binding | ISO | CHRNA4 (Homo sapiens) | 6480464 | CTD | [CHRNB4 protein binds to CHRNA4 protein] which binds to epibatidine; epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein] | PMID:14645658 PMID:9454827 | Chrna4 | multiple interactions | ISO | Chrna4 (Mus musculus) | 6480464 | CTD | Tretinoin promotes the reaction [epibatidine binds to CHRNA4 protein] | PMID:17203487 | Chrna4 | multiple interactions | ISO | CHRNA4 (Homo sapiens) | 6480464 | CTD | Acetylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Acetylthiocholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Alcuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Carbachol inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Choline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; cytisine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; decamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dihydro-beta-Erythroidine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Dimethylphenylpiperazinium Iodide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; epibatidine binds to and results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; epibatidine results in increased activity of [CHRNA4 protein binds to CHRNB2 protein]; Hexamethonium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; methyllycaconitine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Nicotine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Pancuronium inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Physostigmine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; subecholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Tubocurarine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Vecuronium Bromide inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] | PMID:14645658 PMID:22060139 | |
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