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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2802
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hmgb1
Name: high mobility group box 1
Acc ID: CHEBI:4784
Term: enalapril
Definition: A dicarboxylic acid monoester that is ethyl 4-phenylbutanoate in which a hydrogen alpha to the carboxy group is substituted by the amino group of L-alanyl-L-proline (S-configuration).
Chemical ID: MESH:D004656
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgb1multiple interactionsEXP 6480464CTDEnalapril inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein]PMID:19114890
Hmgb1multiple interactionsISOHmgb1 (Mus musculus)6480464CTDEnalapril inhibits the reaction [endotoxin, Escherichia coli results in increased secretion of HMGB1 protein]PMID:19114890
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