GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Nlrp3 | multiple interactions | EXP | | 6480464 | CTD | NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein] | PMID:18403674 | Nlrp3 | increases expression | ISO | NLRP3 (Homo sapiens) | 6480464 | CTD | Asbestos, Crocidolite results in increased expression of NLRP3 mRNA; Asbestos, Crocidolite results in increased expression of NLRP3 protein | PMID:23937860 PMID:24885895 | Nlrp3 | multiple interactions | ISO | NLRP3 (Homo sapiens) | 6480464 | CTD | Dactinomycin inhibits the reaction [Asbestos, Crocidolite results in increased expression of NLRP3 mRNA]; Interleukin 1 Receptor Antagonist Protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of NLRP3 mRNA]; NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased secretion of CXCL8 protein]; NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased secretion of FGF2 protein]; NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein]; NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein]; NLRP3 protein affects the reaction [Asbestos, Crocidolite results in increased secretion of TFPI2 protein]; NLRP3 protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of HMGB1 protein]; NLRP3 protein promotes the reaction [Asbestos, Crocidolite results in increased secretion of IL1B protein] | PMID:18403674 PMID:23937860 PMID:28056339 | | ||||||||||||||||||||||
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