GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ERBB2 | decreases expression | EXP | | 6480464 | CTD | afimoxifene results in decreased expression of ERBB2 mRNA | PMID:15072547 | ERBB2 | decreases response to substance | EXP | | 6480464 | CTD | ERBB2 results in decreased susceptibility to afimoxifene | PMID:21233418 | ERBB2 | multiple interactions | EXP | | 6480464 | CTD | afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [Estrogens results in decreased expression of ERBB2 mRNA] | PMID:12439862 PMID:21233418 | ERBB2 | increases expression | ISO | Erbb2 (Mus musculus) | 6480464 | CTD | afimoxifene results in increased expression of ERBB2 mRNA | PMID:17640349 | |
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