GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp2d22 | decreases activity | EXP | | 6480464 | CTD | Tamoxifen results in decreased activity of CYP2D6 protein | PMID:18420780 | Cyp2d22 | affects metabolic processing | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | CYP2D6 protein affects the metabolism of Tamoxifen | PMID:15632378 PMID:15961252 PMID:19189212 | Cyp2d22 | affects response to substance | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | CYP2D6 gene polymorphism affects the susceptibility to Tamoxifen; CYP2D6 polymorphism affects the susceptibility to Tamoxifen | PMID:19189210 PMID:19189212 PMID:23786776 | Cyp2d22 | decreases response to substance | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | CYP2D6 gene polymorphism results in decreased susceptibility to Tamoxifen | PMID:20309015 | Cyp2d22 | increases expression | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in increased expression of CYP2D6 protein | PMID:19812351 | Cyp2d22 | increases metabolic processing | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | CYP2D6 protein results in increased metabolism of Tamoxifen | PMID:20123649 | Cyp2d22 | increases response to substance | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | CYP2D6 gene polymorphism results in increased susceptibility to Tamoxifen; CYP2D6 protein results in increased susceptibility to Tamoxifen | PMID:19244106 PMID:21152245 | Cyp2d22 | multiple interactions | ISO | CYP2D6 (Homo sapiens) | 6480464 | CTD | [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Tamoxifen; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in decreased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of 1-(4-hydroxyphenyl)-1,2-diphenyl-1-butene; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of N-desmethyltamoxifen; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased abundance of Tamoxifen metabolite; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased glucuronidation of 4-hydroxy-N-desmethyltamoxifen; [CYP2D6 protein results in increased metabolism of Tamoxifen] which results in increased glucuronidation of N-desmethyltamoxifen; CYP2D6 gene affects the abundance of and affects the susceptibility to Tamoxifen | PMID:20124171 PMID:23397584 PMID:29285606 | | ||||||||||||||||||||||
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