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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn1a
Name: cyclin-dependent kinase inhibitor 1A
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn1aincreases expressionISOCDKN1A (Homo sapiens)6480464CTDCelecoxib results in increased expression of CDKN1A mRNA; Celecoxib results in increased expression of CDKN1A proteinPMID:16136956 PMID:19141979 PMID:19706164 PMID:21737646
Cdkn1aincreases localizationISOCDKN1A (Homo sapiens)6480464CTDCelecoxib results in increased localization of CDKN1A proteinPMID:19706164
Cdkn1amultiple interactionsISOCDKN1A (Homo sapiens)6480464CTD[Atorvastatin co-treated with Celecoxib] results in increased expression of CDKN1A protein; Celecoxib promotes the reaction [Valproic Acid results in increased expression of CDKN1A protein]; TP53 affects the reaction [Celecoxib results in increased expression of CDKN1A mRNA]; Valproic Acid promotes the reaction [Celecoxib results in increased expression of CDKN1A protein]PMID:18172863 PMID:19706164 PMID:21737646
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