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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1318015
Species: Mus musculus
RGD Object: Gene
Symbol: Nlrp3
Name: NLR family, pyrin domain containing 3
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nlrp3increases expressionISONlrp3 (Rattus norvegicus)6480464CTDCyclophosphamide results in increased expression of NLRP3 proteinPMID:35762198
Nlrp3multiple interactionsISONlrp3 (Rattus norvegicus)6480464CTDNitroarginine inhibits the reaction [Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of NLRP3 protein]]; Simvastatin inhibits the reaction [Cyclophosphamide results in increased expression of NLRP3 protein]PMID:35762198
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