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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346751
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2B6
Name: cytochrome P450 family 2 subfamily B member 6
Acc ID: CHEBI:39106
Term: pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.
Chemical ID: MESH:C030984
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2B6increases expressionEXP 6480464CTDpyrene results in increased expression of CYP2B6 mRNAPMID:26160115 PMID:33249052
CYP2B6multiple interactionsEXP 6480464CTD[fluoranthene co-treated with Benzo(a)pyrene] inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA]; [pyrene co-treated with Benzo(a)pyrene] inhibits the reaction [fluoranthene results in increased expression of CYP2B6 mRNA]; [pyrene co-treated with fluoranthene] results in increased expression of CYP2B6 mRNA; [pyrene results in increased activity of NR1I3 protein] which results in increased expression of CYP2B6 mRNA; Benzo(a)pyrene inhibits the reaction [pyrene results in increased expression of CYP2B6 mRNA]PMID:26160115 PMID:33249052
CYP2B6increases expressionISOCyp2b10 (Mus musculus)6480464CTDpyrene results in increased expression of CYP2B10 mRNAPMID:17618724 PMID:26160115
CYP2B6multiple interactionsISOCyp2b10 (Mus musculus)6480464CTDNR1I3 gene mutant form inhibits the reaction [pyrene results in increased expression of CYP2B10 mRNA]PMID:26160115
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