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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3397
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Prkcg
Name: protein kinase C, gamma
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prkcgaffects localizationEXP 6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCG proteinPMID:14975926
Prkcgaffects localizationISOPRKCG (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate affects the localization of PRKCG proteinPMID:19447859 PMID:25866363
Prkcgdecreases expressionISOPRKCG (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in decreased expression of PRKCG proteinPMID:15949478
Prkcgincreases activityISOPRKCG (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased activity of PRKCG proteinPMID:15707588
Prkcgmultiple interactionsISOPrkcg (Mus musculus)6480464CTD[Tetradecanoylphorbol Acetate co-treated with Calcium] inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Morphine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]PMID:18652891
Prkcgmultiple interactionsISOPRKCG (Homo sapiens)6480464CTDnaringenin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCG protein]PMID:25866363
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