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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10310
Species: Mus musculus
RGD Object: Gene
Symbol: Cd44
Name: CD44 antigen
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd44multiple interactionsEXP 6480464CTDChlorpromazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein]; Cycloheximide inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of CD44 protein]; Tetradecanoylphorbol Acetate promotes the reaction [CD44 protein binds to Hyaluronic Acid]; Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of CD44 protein; Trifluoperazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein]; Verapamil inhibits the reaction [Tetradecanoylphorbol Acetate promotes the reaction [CD44 protein binds to Hyaluronic Acid]]; Verapamil inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of CD44 protein]; W 7 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein]PMID:9929743
Cd44multiple interactionsISOCD44 (Homo sapiens)6480464CTD[bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD44 mRNA]; [Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CD44 mRNAPMID:15477007
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