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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfe2l2
Name: NFE2 like bZIP transcription factor 2
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2affects expressionISONfe2l2 (Mus musculus)6480464CTDperfluorooctanoic acid affects the expression of NFE2L2 mRNAPMID:18281256
Nfe2l2decreases expressionISONFE2L2 (Homo sapiens)6480464CTDperfluorooctanoic acid results in decreased expression of NFE2L2 mRNAPMID:23567314 PMID:32790152
Nfe2l2increases activityISONfe2l2 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased activity of NFE2L2 proteinPMID:30114225 PMID:30203046
Nfe2l2increases expressionISONfe2l2 (Mus musculus)6480464CTDperfluorooctanoic acid results in increased expression of NFE2L2 mRNAPMID:18281256 PMID:30685356
Nfe2l2increases response to substanceISONfe2l2 (Mus musculus)6480464CTDNFE2L2 gene mutant form results in increased susceptibility to perfluorooctanoic acidPMID:33812015
Nfe2l2multiple interactionsISONfe2l2 (Mus musculus)6480464CTD[CYP2A5 promoter mutant form results in decreased activity of NFE2L2 protein] which results in decreased susceptibility to perfluorooctanoic acid; NFE2L2 gene mutant form promotes the reaction [perfluorooctanoic acid results in increased activity of CASP3 protein]; PPARA protein affects the reaction [perfluorooctanoic acid results in increased expression of NFE2L2 mRNA]PMID:18281256 PMID:29788535 PMID:33812015
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