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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606038
Species: Homo sapiens
RGD Object: Gene
Symbol: DNMT3A
Name: DNA methyltransferase 3 alpha
Acc ID: CHEBI:35549
Term: perfluorooctanoic acid
Definition: A fluoroalkanoic acid that is perfluorinated octanoic acid.
Chemical ID: MESH:C023036
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DNMT3Adecreases expressionEXP 6480464CTDperfluorooctanoic acid results in decreased expression of DNMT3A proteinPMID:26879310
DNMT3Aincreases expressionEXP 6480464CTDperfluorooctanoic acid results in increased expression of DNMT3A mRNAPMID:22425687
DNMT3Amultiple interactionsEXP 6480464CTD[bisphenol S co-treated with perfluorooctanoic acid] results in increased expression of DNMT3A mRNAPMID:37834465
DNMT3Adecreases expressionISODnmt3a (Mus musculus)6480464CTDperfluorooctanoic acid results in decreased expression of DNMT3A mRNAPMID:32320774
DNMT3Amultiple interactionsISODnmt3a (Mus musculus)6480464CTD[Dexamethasone co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with perfluorooctanoic acid] results in increased expression of DNMT3A mRNAPMID:29094436
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