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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736485
Species: Mus musculus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of SQSTM1 mRNA; Cadmium Chloride results in decreased expression of SQSTM1 proteinPMID:29486218 PMID:35843418
Sqstm1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of SQSTM1 mRNA; Cadmium Chloride results in increased expression of SQSTM1 proteinPMID:11958953 PMID:15501611 PMID:30030080
Sqstm1multiple interactionsEXP 6480464CTD3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 mRNA]; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein; [Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein; Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 mRNA]; Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; Cholesterol inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; MT1 affects the reaction [Cadmium Chloride results in increased expression of SQSTM1 mRNA]; MT2 affects the reaction [Cadmium Chloride results in increased expression of SQSTM1 mRNA]; PINK1 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein]PMID:11958953 PMID:29486218 PMID:31862506 PMID:34952138 PMID:35843418 PMID:36336208 PMID:37022104
Sqstm1decreases expressionISOSqstm1 (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of SQSTM1 proteinPMID:29218509 PMID:33127495
Sqstm1decreases expressionISOSQSTM1 (Homo sapiens)6480464CTDCadmium Chloride results in decreased expression of SQSTM1 proteinPMID:33127495
Sqstm1increases expressionISOSqstm1 (Rattus norvegicus)6480464CTDCadmium Chloride results in increased expression of SQSTM1 mRNAPMID:22110744
Sqstm1increases expressionISOSQSTM1 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of SQSTM1 mRNA; Cadmium Chloride results in increased expression of SQSTM1 proteinPMID:25596134 PMID:34580807
Sqstm1multiple interactionsISOSqstm1 (Rattus norvegicus)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein; brusatol inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein]; NFE2L2 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SQSTM1 protein]PMID:34695510
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein]; 4-phenylbutyric acid inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein; ATG5 protein affects the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein]; Carbonyl Cyanide m-Chlorophenyl Hydrazone inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein]; salubrinal inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]PMID:31319114 PMID:33127495 PMID:34481905 PMID:36336208
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