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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732442
Species: Mus musculus
RGD Object: Gene
Symbol: Txn1
Name: thioredoxin 1
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Txn1affects localizationEXP 6480464CTDCadmium Chloride affects the localization of TXN1 proteinPMID:22961094
Txn1increases expressionEXP 6480464CTDCadmium Chloride results in increased expression of TXN1 mRNAPMID:22677785
Txn1multiple interactionsEXP 6480464CTD[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of TXN1 mRNAPMID:19840844
Txn1affects localizationISOTXN (Homo sapiens)6480464CTDCadmium Chloride affects the localization of TXN proteinPMID:18261755 PMID:22961094
Txn1increases expressionISOTXN (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of TXN mRNA; Cadmium Chloride results in increased expression of TXN proteinPMID:16440303 PMID:25596134 PMID:26525392
Txn1increases oxidationISOTXN (Homo sapiens)6480464CTDCadmium Chloride results in increased oxidation of TXN proteinPMID:16337887
Txn1multiple interactionsISOTXN (Homo sapiens)6480464CTDCytochalasin D inhibits the reaction [Cadmium Chloride affects the localization of TXN protein]PMID:22961094
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